Galectin 3 anticorps

N° du produit ABIN2689513

Cet anticorps anti-Galectin 3 est un anticorps Souris Monoclonal détectant Galectin 3 dans IHC (f) et ICS. Adapté pour Humain. Ce Primary Antibody a été cité dans 4+ publications.

Aperçu rapide pour Galectin 3 anticorps (ABIN2689513)

Antigène: Galectin 3 (LGALS3)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Galectin 3 est non-conjugé

Application: Immunohistochemistry (Formalin-fixed Sections) (IHC (f)), Intracellular Staining (ICS)

Clone: B2C10

Détail du produit anti-Galectin 3 anticorps

Marque: BD Pharmingen™

Attributs du produit: Reacts with Galectin-3, a 30 kDa protein, a member of a newly defined family of β-galactoside-binding animal lectins. It has been previously referred to as IgE-binding protein (εBP) and carbohydrate-binding protein 35 (CBP35). It is expressed on many tissues and cell types. Galectin-3 can be found in the nucleus and/or cytoplasm, on the cell surface and in the extra cellular matrix. Its function has been found to be diverse. It has been reported to be markedly elevated in the nucleus of proliferating cells, suggesting that Galectin-3 may play a role in cell growth regulation. Studies of Galectin-3 on the cell surface have shown it to be a non-integrin, laminin-binding protein, suggesting its role in cell adhesion to basement membranes. Monoclonal antibody B2C10 is suitable for immunohistochemical staining of parafin-embedded tissue sections. Profile of permeabilized peripheral blood monocytes analyzed by flow cytometry. Second step staining with Cat. No. 555988.

BD Pharmingen™ Purified Mouse Anti-Human Galectin-3 - Purified - Clone B2C10 - Isotype Mouse IgG1, κ - Reactivity Hu - 0.1 mg

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Isotype: IgG1 kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store undiluted at 4°C.

Références pour anticorps anti-Galectin 3 (ABIN2689513)

Cortegano, del Pozo, Cárdaba, de Andrés, Gallardo, del Amo, Arrieta, Jurado, Palomino, Liu, Lahoz: "Galectin-3 down-regulates IL-5 gene expression on different cell types." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 161, Issue 1, pp. 385-9, (1998) (PubMed).

Liu, Hsu, Zuberi, Hill, Shenhav, Kuwabara, Chen: "Modulation of functional properties of galectin-3 by monoclonal antibodies binding to the non-lectin domains." dans: Biochemistry, Vol. 35, Issue 19, pp. 6073-9, (1996) (PubMed).

Mey, Leffler, Hmama, Normier, Revillard: "The animal lectin galectin-3 interacts with bacterial lipopolysaccharides via two independent sites." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 156, Issue 4, pp. 1572-7, (1996) (PubMed).

Cherayil, Weiner, Pillai: "The Mac-2 antigen is a galactose-specific lectin that binds IgE." dans: The Journal of experimental medicine, Vol. 170, Issue 6, pp. 1959-72, (1990) (PubMed).

Détails sur Galectin 3

Antigène: Galectin 3 (LGALS3)

Autre désignation: Galectin-3

Classe de substances: Chemical

Pathways: Signalisation RTK